Profile Project

Information updated to: 31/08/2016

Project

NUOVI FARMACI BIOTECNOLOGICI ATTIVI ATTRAVERSO LA MODULAZIONE DELL’ATTIVITÀ RECETTORIALE

Code PON01_02464
Field/s Health and wellbeing
Description The present project contains activities of both industrial research and industrial development, to develop and validate novel molecules acting as mimetics of neurotrophins and molecules inhibiting neo-angiogenesis. Recently, some of the Research Units of the present Project have set up: Line 1) novel low molecular weight non-peptidic compounds that possess metabolic activities in vitro superimposable to those of native NGF: such molecules selectively interact with TrkA receptor molecule, induce its autophosphorylation and activate downstream signalling pathways, thus modulating the function of key enzymes and proteins essential for cell survival (MAPK, ERK, Bcl-2, etc.): on this basis, they are essentially mimetics of the native neurotrophin. One of the major activities of NGF mimetics so far detected is the marked inhibition of the apoptotic process, consistent with the activities of NGF itself. This experimental line shall therefore be devoted to setting up pharmaceutical preparations for the following diseases: neurodegenerative disorders (such as Alzheimer disease or Parkinson disease); pressure or ischemic ulcers; neurotrophic corneal ulcers and glaucoma retinal damage; acute myocardial or cerebral ischemia; neoplastic disorders, particularly of the Central Nervous System. Line 2) drugs originating from synthetic peptides able to inhibit neoangiogenesis through the inhibition of endothelial cell migration. The family of peptides under investigation is composed of low molecular weight compounds, easily prepared through chemical synthesis and easily purified through low cost industrial procedures. As the main activity of such peptides is the blockade of new vessels growth (anti-angiogenic activity), their potential applications focus onto diseases taking advantage from inhibition of neoangiogenesis, such as the growth or metastatization of solid tumors, the neovascular proliferation of diabetic retinopathy or of senile macular degeneration, particularly in its wet form. Within the present project, such compounds will be studied for their use in diabetic retinopathy and senile macular degeneration. Both Project Lines include Phase I and Phase II clinical studies.
Total cost 10,737,163.95 euro
Public contribution
Total public contribution
8,640,790.14 euro

NOP R&C contribution
6,686,176.26 euro

PAC contribution
0.00 euro

Contribution from other funds
1,954,613.88 euro
Distribution Advancement of distribution in %
Total amount distributed
2,264,065.84 euro

NOP R&C distributed amount
2,105,628.34 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
158,437.50 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
University 2
Micro business 1
Small business 1
Total Beneficiaries 4

Seconda Università degli Studi di Napoli

Tax File Number: 02044190615
Unique Project Code: B61C11002300005
Location of financial commitments: Campania
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 1,917,800.00 euro
Public contribution Total
1,630,130.00 euro 		Eligible of NOP R&C
1,630,130.00 euro
Distribution Total
503,880.00 euro 		Amount of NOP R&C
503,880.00 euro

Date of last distribution of NOP R&C
-

UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II

Tax File Number: 00876220633
Unique Project Code: B61C11002290005
Location of financial commitments: Campania
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 2,695,320.00 euro
Public contribution Total
2,291,022.00 euro 		Eligible of NOP R&C
2,291,022.00 euro
Distribution Total
1,164,772.00 euro 		Amount of NOP R&C
1,164,772.00 euro

Date of last distribution of NOP R&C
-

CONSORZIO PITECNOBIO

Tax File Number: 04618840872
Unique Project Code: B51C11000680005
Location of financial commitments: Non disponibile
Type: Micro business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 4,963,000.00 euro
Public contribution Total
3,913,654.07 euro 		Eligible of NOP R&C
2,218,725.45 euro
Distribution Total
496,437.50 euro 		Amount of NOP R&C
338,000.00 euro

Date of last distribution of NOP R&C
-

BIOOS ITALIA SRL

Tax File Number: 01618170441
Unique Project Code: B21C11000800005
Location of financial commitments: Non disponibile
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 1,161,043.95 euro
Public contribution Total
805,984.07 euro 		Eligible of NOP R&C
546,298.81 euro
Distribution Total
98,976.34 euro 		Amount of NOP R&C
98,976.34 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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