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Information updated to: 31/08/2016

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Project

PIATTAFORME NANOTECNOLOGICHE INNOVATIVE PER IL DELIVERY DI FARMACI IN OFTALMOLOGIA

Code PON01_00110

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Description
Beneficiaries
Objectives

Results

Field/s	Cultural goods and services, Health and wellbeing
Description	The aim of this project is the study and preclinical/clinical validation of new technological platforms of drug delivery applied to the set-up of new experimental pharmaceutical formulations in the field of ophthalmology. The problem of pharmaceutical formulation in ophthalmology is particularly relevant because both the anterior and posterior segments of the eye possess anatomical, structural and functional characteristics that strongly reduce the bioavailability of the drugs administered to target tissues. This project will study highly innovative delivery systems based on nanotechnogical plattforms to target some drugs to the anterior segment and other drugs to the posterior segment of the eye. The major problem in ocular therapeutics is the attainment of an optimal drug concentration at the site of action. For the anterior segment drug delivery, common routes of administration include topical instillation and subconjuntival injection. Bioavailability of drugs from eye drops is severely impeded by a short precorneal residence time of the drug, mainly due to mechanisms of the eye that protect from foreign materials. Therapies addressed to the posterior segment of the eye are difficult too, due to very low bioavailability of the drugs on the target tissues. In fact these structures are scarcely targeted by drugs topically administered on the surfaces of the eye; consequently it is necessary to administer drugs by systemical route (with high risk of adverse effects on other structures) or to adopt invasive strategies, such as intravitreal or subconjunctival injections. To overcome the problems of conventional ocular therapy, such as short residence time, drug drainage and frequently instillation, newer drug delivery systems are being explored to improve ocular bioavailability. In general ocular bioavailability may be enhanced by increasing corneal drug penetration and by prolonging precorneal residence time of instilled drugs. Various approaches such as viscosity enhancement, use of muco-adhesive agents, hydrogels, microparticles, nanoparticles, microemulsion, lyposomes and pro-drugs have been studied. In order to solve the typical problems of the conventional formulations, in this project innovative formulations based on nanosystems will be studied to obtain an improvement of the bioavailability of the drugs on the target tissues.
Total cost	8,726,936.77 euro
Public contribution		Total public contribution 6,784,924.75 euro NOP R&C contribution 5,498,202.25 euro PAC contribution 0.00 euro Contribution from other funds 1,286,722.50 euro
Distribution	Advancement of distribution in %	Total amount distributed 5,651,550.47 euro NOP R&C distributed amount 4,687,233.12 euro PAC distributed amount 0.00 euro Amount distributed with other funds 964,317.35 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
NOP R&C admitted contribution
PAC admitted contribution
Contribution with other funds

Distribution – The following elements are reported:

Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
PAC distributed amount – amount distributed to financing of project to be valued on PAC
Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary

Public commitment for beneficiary

University	2
Micro business	1
Public research organisation	1
Total Beneficiaries	4

Università degli studi di Catania

Tax File Number: 02772010878
Unique Project Code: E61H11000160005
Location of financial commitments: Sicilia

Type: University

See beneficiary profile >

Presentation date	09/04/2010
Approval date	10/02/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	3,204,046.77 euro
Public contribution	Total 2,723,439.75 euro	Eligible of NOP R&C 2,723,439.75 euro
Distribution	Total 2,656,250.00 euro	Amount of NOP R&C 2,656,250.00 euro Date of last distribution of NOP R&C -

SOOFT ITALIA SPA

Tax File Number: 01624020440
Unique Project Code: B91C11000750005
Location of financial commitments: Non disponibile

Type: Micro business

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Presentation date	09/04/2010
Approval date	23/03/2015
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	3,237,690.00 euro
Public contribution	Total 2,119,065.00 euro	Eligible of NOP R&C 1,067,155.00 euro
Distribution	Total 1,123,132.97 euro	Amount of NOP R&C 323,375.62 euro Date of last distribution of NOP R&C -

Università della Calabria

Tax File Number: 80003950781
Unique Project Code: B21H11000120005
Location of financial commitments: Calabria

Type: University

See beneficiary profile >

Presentation date	09/04/2010
Approval date	10/02/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	1,160,900.00 euro
Public contribution	Total 986,765.00 euro	Eligible of NOP R&C 986,765.00 euro
Distribution	Total 986,765.00 euro	Amount of NOP R&C 986,765.00 euro Date of last distribution of NOP R&C -

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B11H11000130005
Location of financial commitments: Calabria, Extra convergenza

Type: Public research organisation

See beneficiary profile >

Presentation date	09/04/2010
Approval date	10/02/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	1,124,300.00 euro
Public contribution	Total 955,655.00 euro	Eligible of NOP R&C 720,842.50 euro
Distribution	Total 885,402.50 euro	Amount of NOP R&C 720,842.50 euro Date of last distribution of NOP R&C -

Axis - Operational objective	I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action	Strategic scientific and technological areas
Action line	Industrial Research (Go to)
Instrument of implementation	Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective	Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions