Profile Project

Information updated to: 31/08/2016

Project

Identificazione di biomarcatori e sviluppo di metodidiagnostici e terapeutici nel campo dell’oncologia e dellabiologia vascolare.

Code PON01_01078
Field/s Health and wellbeing
Description This project aims to understand the molecular mechanisms of cancer pathology with the final scope to identify biomarkers as molecular targets of new anticancer substances and safety biomarkers as preclinical signals of drug induced vascular injury. Two fields of great interest for the human health system and, as consequence, for pharmacological research, are those related to neoplasie and to drug-induced side effects. In fact at epidemiological level neoplasie constitute the second cause of death after cardiovascular pathologies. The impact of such pathologies in the industrialized countries follows an exponential trend similar to the increase registered in the average survival index of population (aging) causing a significant growth in the pharmaceutical oncology market. In the pharmacological research field the efforts are aimed to obtain new biologics that more effectively hit the targets while diminishing the unpleasant side effect commonly associated to their use. In fact to date almost all the available drugs are characterized by a high therapeutic index that is counterbalanced by negative unavoidable side effects that include a wide range of pharmacological reactions, some of toxic nature, which can appear during the treatment. One of these negative side effects is represented by drug-induced vascular injury and, at present, new technologies such as genomics, proteomics and bioinformatics, represent a valid tool to characterize the molecular mechanisms linked to lesions. To resolve these issue the scientific research in general, and biopharmaceutical research in particular, aim to indentify new biomarkers and to develop innovative diagnostic and therapeutic tools. The present project focus on two objectives: the identification and validation of new biomarkers studying the molecular bases of oncological pathologies and the mode of action of antitumor compounds; understanding of those mechanisms responsible for some negative side effects related to the use of drugs like those associated with vascular damage. At present, biomedicine is in the midst of a technological revolution, driven by advances in genomics, proteomics, metabolomics and bioinformatics. Scientists strive to explore biomarkers and their possible role in the diagnosis, treatment and prognosis of tumor diseases. Researchers are trying to develop better screening and treatment options in the fight against the malignancy, as well as searching for proteins that may serve as biomarkers to detect and locate incipient cancer, serve as possible drug target, monitor response to therapy and predict the chance of recurrence after treatment has ended. Moreover, being biomarkers indicative of a biological change caused by the drug, they are an essential mean of pharmaceutical research that allows selecting, at an early stage of their development, the most successful molecules. Aim of this project will be the following areas of research: Identification of new molecular targets in the field of vascular biology; Research on new therapeutic targets to develop more efficacious and safe antitumor drugs; Implementation of databases of gene and protein expression profile as comparative and predictive tool for biomarkers identification and drug development.
Total cost 18,690,905.00 euro
Public contribution
Total public contribution
13,337,682.00 euro

NOP R&C contribution
11,515,182.00 euro

PAC contribution
0.00 euro

Contribution from other funds
1,822,500.00 euro
Distribution Advancement of distribution in %
Total amount distributed
8,814,625.47 euro

NOP R&C distributed amount
8,657,875.47 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
156,750.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
University 3
Research Organisation 2
Large business 1
Public research organisation 1
Medium business 1
Total Beneficiaries 8

Università degli studi di Catania

Tax File Number: 02772010878
Unique Project Code: E91H11000030005
Location of financial commitments: Sicilia, Extra convergenza
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 2,000,000.00 euro
Public contribution Total
1,700,000.00 euro 		Eligible of NOP R&C
1,487,500.00 euro
Distribution Total
1,551,250.00 euro 		Amount of NOP R&C
1,487,500.00 euro

Date of last distribution of NOP R&C
-

BIOGEM S.C.a r.l.

Tax File Number: 02071230649
Unique Project Code: B91H11000440005
Location of financial commitments: Campania
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 1,000,000.00 euro
Public contribution Total
850,000.00 euro 		Eligible of NOP R&C
850,000.00 euro
Distribution Total
850,000.00 euro 		Amount of NOP R&C
850,000.00 euro

Date of last distribution of NOP R&C
-

C.I.R.C.M.S.B.

Tax File Number: 04434750727
Unique Project Code: B91H11000430005
Location of financial commitments: Puglia
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 250,000.00 euro
Public contribution Total
212,500.00 euro 		Eligible of NOP R&C
212,500.00 euro
Distribution Total
162,460.32 euro 		Amount of NOP R&C
162,460.32 euro

Date of last distribution of NOP R&C
-

Consorzio di Ricerca ed Innovazione in Oncologia e Medicina CRIOMM

Tax File Number: 04879310870
Unique Project Code: B81H11001100005
Location of financial commitments: Sicilia, Extra convergenza
Type: Large business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 4,500,000.00 euro
Public contribution Total
2,925,000.00 euro 		Eligible of NOP R&C
1,625,000.00 euro
Distribution Total
127,288.15 euro 		Amount of NOP R&C
127,288.15 euro

Date of last distribution of NOP R&C
-

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B81H11001090005
Location of financial commitments: Campania, Sicilia, Extra convergenza
Type: Public research organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 2,250,000.00 euro
Public contribution Total
1,912,500.00 euro 		Eligible of NOP R&C
1,700,000.00 euro
Distribution Total
1,763,750.00 euro 		Amount of NOP R&C
1,700,000.00 euro

Date of last distribution of NOP R&C
-

Università degli studi di Palermo

Tax File Number: 80023730825
Unique Project Code: B71H11000280005
Location of financial commitments: Sicilia
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 1,000,000.00 euro
Public contribution Total
850,000.00 euro 		Eligible of NOP R&C
850,000.00 euro
Distribution Total
850,000.00 euro 		Amount of NOP R&C
850,000.00 euro

Date of last distribution of NOP R&C
-

Myrmex SpA

Tax File Number: 04500860962
Unique Project Code: B51H11000930005
Location of financial commitments: Sicilia, Extra convergenza
Type: Medium business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 7,190,905.00 euro
Public contribution Total
4,462,682.00 euro 		Eligible of NOP R&C
4,365,182.00 euro
Distribution Total
3,084,877.00 euro 		Amount of NOP R&C
3,055,627.00 euro

Date of last distribution of NOP R&C
-

Università degli Studi Magna Grecia di Catanzaro

Tax File Number: 97026980793
Unique Project Code: B31H11000250005
Location of financial commitments: Campania, Calabria
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 26/11/2012
Start of activity Expected date
15/07/2010 		Effective date
15/07/2010
End of activity Expected date
30/05/2015 		Effective date
-
Total cost 500,000.00 euro
Public contribution Total
425,000.00 euro 		Eligible of NOP R&C
425,000.00 euro
Distribution Total
425,000.00 euro 		Amount of NOP R&C
425,000.00 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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